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. 2017 May 4;58(7):1362–1373. doi: 10.1194/jlr.M074849

Fig. 11.

Fig. 11.

Hepatic ketone body production and muscle and cardiac enzyme activities in Wistar male rats given 100 mg/kg 1-triple TTA for 3 weeks compared with controls. A: Mitochondrial HMG-CoA synthase activity in liver. B: Hepatic mRNA level of mitochondrial Hmgcs2. C: NEFA plasma concentration. D: Plasma concentration of the ketone body, β-hydroxybutyrate. E: Ratio of β-hydroxybutyrate and NEFA. F: Oxalate CoA-transferase activity in muscle and heart tissue. G: CPT-II activity in muscle and heart tissue. Values are shown as means and SD (n = 5–8). Significant difference compared with controls was determined with Student’s t-test (*P ≤ 0.05, ****P ≤ 0.0001).