Fig. 2. Molecular design models of TEM azF variants. (A) Model of TEMY105azF (yellow) aligned with wt TEM β-lactamase (grey; PDB ; 1btl), with the active site S70 shown as stick representation. (B) Alignment of the TEMP174azF (cyan) with wt TEM (grey; PDB ; 1btl). The region highlighted in red covers residues 173–175. (C) Interaction of AzF174 with neighbouring residues.
