Table 4.
Comparison of median and inter quartile range (IQR) of day 7 LF median plasma concentration between different genotype groups in pregnant women with uncomplicated Plasmodium falciparum infection using Kruskal–Wallis ANOVA
| Plasma lumefantrine concertation at day 7 | |||
|---|---|---|---|
| n | Median (IQR) | P value | |
| No of CYP2B6*1 allele | |||
| Zero | 17 | 650.0 (285.8–1603.2) | 0.85 |
| One | 37 | 671.6 (280.0–1935.3) | |
| Two | 28 | 672.0 (350.0–2161.8) | |
| CYP3A4*1B | |||
| *1A/*1A | 3 | 294.6 (270.0–319.2) | 0.24 |
| *1A/*1B | 38 | 689.7 (354.1–1935.3) | |
| *1B/*1B | 51 | 644.6 (280.0–2615.0) | |
| No of CYP3A5*1 allele | |||
| Zero | 27 | 716.6 (340.9–2109.4) | 0.039 |
| One | 47 | 689.7 (280.0–3059.1) | |
| Two | 18 | 354.2 (285.8–1603.2) | |
| ABCB1 c.4036AG | |||
| AA | 54 | 585.2 (330.0–2615.0) | 0.28 |
| AG | 26 | 710.7 (282.3–2161.8) | |
| GG | 12 | 1055.1 (285.8–2109.4) | |
No of CYP2B6*1 allele: two, *1/*1; one, heterozygous for *6 or *18; zero, homozygous for *6 or *18 or combination thereof
No of CYP3A5*1 allele: two, *1/*1; one, heterozygous for *3, *6 or *7; zero, homozygous for *3, *6 or *7, combination thereof