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. 2017 Jul 4;14:43. doi: 10.1186/s12986-017-0194-2

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Study design. a Structure of piperine (C₁₇H₁₉NO₃; molecular weight: 285.34 Da). b Study design showing the exercise protocol. Mice were administered 5 mg/kg piperine orally 30 min prior to running on a treadmill for 1 h. After exercise, mice were sacrificed, and tissues were collected