Table 1.

Characteristics of studies included in the meta-analysis

Author	Year	Country	Ethnicity	Disease	Etiology of HF	Genotyping methods	Total number	Number		Gender (M/F)		Age (Year)
								CC	CT + TT	CC	CT + TT	CC	CT + TT
Tousoulis D [10]	2014	Greece	Caucasian	Consecutive stable CAD		PCR-RFLP	192	149	43	90/10	93/7	61 ± 11	61 ± 11
Safranow K_a [21]	2009	Poland	Caucasian	Stable CAD with HF	Ischemic (67%); Non-ischemic (22%); Other factors (11%)	PCR-RFLP	97	68	29	55/19	27/3	59.92 ± 8.26	56.4 ± 12.0
Safranow K_b [21]	2009	Poland	Caucasian	Stable CAD without HF		PCR-RFLP	104	74	30	55/13	20/9	58.3 ± 8.6	57.9 ± 8.6
de Groote P [15]	2006	France	Caucasian	Stable CHF	Ischemic (42.57%); Non-ischemic (57.43%)	PCR-RFLP	686	517	169	415/102	136/33	55 ± 13	57 ± 13
Collins RP [14]	2006	New Zealand	Caucasian	HF	Irrespective of etiology	PCR-RFLP	357	279	78	167/167	51/48	74.3 ± 0.62	75.4 ± 0.95
Agewall S [22]	2006	Norway	Caucasian	CHD		TaqMan	109	82	27	64/18	18/9	61 ± 11	62 ± 11
Kolek MJ [23]	2005	USA	Mix	HF	Ischemic (58%); Non-ischemic (42%)	PCR-RFLP	1038	843	195	666/177	158/37	60.2 ± 12.2	61.0 ± 12.0
Gastmann A [24]	2004	Germany	Caucasian	CHF	Idiopathic dilated cardiomyopathy (58.89%); Coronary artery disease (22.22%); Other factors (18.89%).	Direct sequencing	90	68	22	51/17	16/6	57.2 ± 13.2	54.0 ± 14.3
Loh E [13]	1999	USA	Caucasian	CHF	Coronary artery disease (52.27%); Idiopathic cardiomyopathy (36.36%); Other factors (11.36%).	ASO-PCR	132	111	21	97/14	16/5	52.1 6 ± 11.6	56.86 ± 7.1

CAD Coronary artery disease, HF Heart failure, CHD Coronary heart disease, SCHF Stable congestive heart failure, CHF Congestive heart failure, PCR-RFLP polymerase chain reaction-restriction fragment Length polymorphism, ASO-PCR Allele-specific Oligonucleotide Polymerase Chain Reaction, Safranow K_a coronary artery disease in patients with heart failure, Safranow K_b coronary artery disease in patients without heart failure