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. 2017 Jul 3;149(7):703–725. doi: 10.1085/jgp.201711771

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© 2017 Drumm et al.

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Figure 6. — The effect of lowering [Ca²⁺]_o on Ca²⁺ transients in ICC-MY. (A) Aa–Ac show normal [Ca²⁺]_o concentrations (2.5 mM) on ICC-MY Ca²⁺ transients. (Aa) Representative heat map showing the summated PTCLs for an entire recording of ICC-MY in control. (Ab) Occurrence map of individually color-coded Ca²⁺ firing sites in the ICC-MY network under control conditions. (Ac) Traces of PTCL activity over an entire recording of the ICC-MY network under control conditions showing PTCL area (dark blue) and PTCL count (brown). (B) Ba–Bc show the effects of lowering [Ca²⁺]_o concentrations to 1 mM on ICC-MY Ca²⁺ transients. (Ba) Representative heat map showing the summated PTCLs of ICC-MY in 1 mM [Ca²⁺]_o conditions. (Bb) Occurrence map of individually color coded Ca²⁺ firing sites in the ICC-MY network in 1 mM [Ca²⁺]_o conditions. (Bc) Traces of PTCL activity over an entire recording of the ICC-MY network under 1 mM [Ca²⁺]_o conditions showing PTCL area (dark blue) and PTCL count (brown). (C) Ca–Cc show the effects of lowering [Ca²⁺]_o concentrations to 0.5 mM on ICC-MY Ca²⁺ transients. (Ca) Representative heat map showing the summated PTCLs of ICC-MY in 0.5 mM [Ca²⁺]_o conditions. (Cb) Occurrence map of individually color coded Ca²⁺ firing sites in the ICC-MY network in 0.5 mM [Ca²⁺]_o conditions. (Cc) Traces of PTCL activity of the ICC-MY network in 0.5 mM [Ca²⁺]_o conditions showing PTCL area (dark blue) and PTCL count (brown). (D) Da–Dc shows the effects of removing [Ca²⁺]_o from the external solution on ICC-MY Ca²⁺ transients. (Da–Dc) Representative heat map showing the summated PTCLs for ICC-MY in 0 mM [Ca²⁺]_o conditions shows no Ca²⁺ activity as shown in the occurrence map (Db) and traces of Ca²⁺ transients (Dc). (E) Summary histogram showing the probability (%) that an individual Ca²⁺ firing site in the ICC-MY cell soma will fire during a CTC cycle in control conditions (black bars), 1 mM [Ca²⁺]_o (red bars), 0.5 mM [Ca²⁺]_o (blue bars) and 0 mM [Ca²⁺]_o (orange bars; n = 5, FOV = 6). (F) Summary histogram showing the probability of an individual Ca²⁺ firing site in the ICC-MY cell processes will fire during a CTC cycle (n = 5, FOV = 6).