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. 2017 Jul 3;149(7):727–749. doi: 10.1085/jgp.201711780

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© 2017 Lu and Hilgemann

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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Figure 13. — Large Cl currents carried by nystatin channels project to similar mixing volumes as cation currents. (A) Nystatin-carried Cl current. Extracellular aspartate was replaced with Cl, and 80 µM nystatin was applied, generating an outward current of 1.8 nA. Removal of Cl then generated peak inward currents of 0.7 to 1 nA with decay time constants of 9.6 and 10.2 s. The peak Cl⁻-activated outward current reached 4 nA and, similar to the nystatin-carried Na current, decayed in a nonexponential fashion. (B) Current–voltage relations during decay of outward current and upon reapplying extracellular Cl. (C) Cytoplasmic Cl concentrations calculated from reversal potentials in B. Cl increases monotonically from 21 mM to 48 mM with a τ of 24.5 s, projecting to a mixing volume of 11 pL.