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By E10.5 SOX7 deficient embryos have profound and widespread defects in vascular development. Whole mount PECAM1 staining of heterozygous (Sox7+/−) and Sox7 knockout (Sox7−/−) embryos at E10.5. (A) Embryo proper, white boxes indicate areas of magnification. Yellow arrows indicate dorsal aorta. (B) Yolk sac vasculature, white boxes indicate areas of magnification. Scale bars: 250 μm.
