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. 2017 Aug;146:31–41. doi: 10.1016/j.mod.2017.05.004

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© 2017 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Fig. 6 — Flk1-Cre Sox7^fl/fl embryos have defects in the dorsal aorta at E8.5. Whole mount PECAM1 staining of control (Sox7^fl/+) and Flk1-Cre Sox7^fl/fl embryos and yolk sac at E8.5 (5–7 somite pairs). (A) 3D projection of embryos embedded within their yolk sacs, white arrows indicated anterior (A), posterior (P), distal (D) and proximal (Pr) axes. (B) Details of the yolk sac vasculature. (C) Paired dorsal aorta region. (D) Magnified view of a posterior region of a single dorsal aorta. Yellow arrows indicate malformation in the dorsal aorta. Scale bars 100 μm (A and C), 50 μm (B and D). Data are representative of at least three embryos with 100% penetrance of the phenotype observed for knockout embryos.