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. 2017 Aug;146:31–41. doi: 10.1016/j.mod.2017.05.004

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© 2017 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 10 — Vav-Cre Sox7^fl/fl mice live to adulthood and have no hematopoietic defects. (A) Immuno-staining of E10.5 wild embryo transversal section. White arrows indicate example of cells co-expressing SOX7, RUNX and cKIT. Upper panels are 40 × magnification; lower panels are 100 × magnification. DA: dorsal aorta. (B and E) Bone marrow, (C) spleen and (D) thymus harvested from aged matched adult WT and Vav-Cre Sox7^fl/fl mice and analysed by flow cytometry, gating first on the viable cells. B cells: CD19⁺ and/or B220⁺; macrophages: CD11b⁺ and F4/80⁺; granulocytes: CD11b⁺ and GR1⁺; Pro erythroblast (Pro E): Ter119^med and CD71⁺; maturing erythroid cells: Ter119^high. Data are presented as mean ± SE, n = 3 mice in each group. No differences were observed between WT and Vav-Cre Sox7^fl/fl populations (Student's paired two-tailed t-test).