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. 2017 Jul 3;216(7):2217–2230. doi: 10.1083/jcb.201601109

Figure 5.

Figure 5.

Analysis of the poly-A RNA and small RNA signatures. (A) Venn diagrams showing the intersections of the specific mRNA sets. DEGs between categories are filtered (P < 0.0001 and fold change >2); intersections and subtractions are performed to obtain minimal gene sets specific for each category. Numbers in bold represent the gene set specific for each category and were used to perform GO analysis using the DAVID database. (B) PCA based on the GO scores obtained for each gene set (left). The loading plot (right) shows the most relevant categories correlated with the axes. Adh, cell adhesion; Anion, anion channel activity; Apop, apoptosis; Ccy, cell cycle; Chro, chromosome; EGF, EGF motif; Hep b, heparin binding; Junc, cell junction; Kina, kinase; Mig, migration; Orga, nonmembrane-bound organelle; Ribo, ribosome; Sign, signal; Vess, vessel; WD40, WD40 repeat. (C) Venn diagrams showing the intersections of the specific miRNA sets. Differentially expressed miRNAs between categories were filtered (P < 0.0001 and fold change >2), and intersections were performed to obtain minimal miRNA sets specific for each category. Numbers in bold represent the gene set specific for each category and were used to perform GO analysis of the miRNA-predicted targets using the miRsystem database. (D) PCA based on the GO scores obtained for each gene set. (E) Enrichment scores of GO categories of the putative targets of each specific miRNA set (miRsystem).