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. 2017 Jul 3;216(7):2217–2230. doi: 10.1083/jcb.201601109

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© 2017 Stik et al.

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Figure 7. — RNA signature changes in LSK cells after contact with AFT EVs. (A) PCA on the global transcriptomes of LSK-naive cells (LSK t0) and LSK cells cultured without cytokines during 18 h with or without AFT EVs (LSK+EV 18h and LSK 18h, respectively). (B) PCA based on the 2,051 DEGs between LSK 18 h and LSK 18 h + EV (one way ANOVA; P < 0.05). (C) Heat map and k-mean hierarchical clustering based on the 2,051 DEGs revealed five gene clusters. (D) GO enrichment analysis of the clusters. FAD, flavin adenine dinucleotide. (E) Relative mean expression of highly expressed AFT EV genes (RPKM >50) in LSK cells before and after contact. (F) Venn diagram of the most abundant genes in AFT EVs and genes highly up-regulated in LSK cells after EV treatment. FC, fold change. (G) Heat map of the common genes in F.