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. 2017 Jul 3;216(7):1875–1877. doi: 10.1083/jcb.201705009

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© 2017 Hammarskjold and Rekosh

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Figure 1. — SRSF5 and SRSF2 shuttle in pluripotent mouse P19 cells and cooperate with NXF1 in the export of mRNAs (model suggested by the data in Botti et al., 2017). (Left) In pluripotent P19 cells, increased arginine methylation of SRSF5 and hypophosphorylation of SRSF2 allow these two SR proteins to interact with NXF1 and mRNA in the export of specific mRNAs to the cytoplasm. NXF1 and SRSF5 stay bound to mRNAs in the cytoplasm, whereas SRSF2 is removed from the complex before translation. (Right) In P19 differentiated neural cells (and HeLa cells), SRSF2 and SRSF5 shuttle poorly and bind mainly to introns and noncoding RNAs. This is accompanied by reduced arginine methylation of SRSF5 and hyperphosphorylation of SRSF2.