Fig. 2.

Early Zelda peaks show different chromatin signatures. Shown are three examples of ZLD peaks, each with a different chromatin signature. a Shown is a distal enhancer of the schnurri gene (shn), where Zelda binds an intronic enhancer (also bound by multiple anterior–posterior transcription factors, not shown), is flanked by H3K4me1 nucleosomes (green) within an H3K27me3 domain (purple). b Shown is the promoter of the bitesize gene (btsz), highlighted with the typical promoter modification (H3K4me3, black) and an asymmetric H3K4me1 domain (green), with flanking H3K27ac and H3K18ac nucleosomes (blue, orange). c Shown is a ZLD peak overlapping the coding region of an inactive gene, with zygotic expression smaller than 0.2 FPKM in mitotic cycles 10–14 [30]. Zelda seems to be transiently bound, with very weak binding by the end of mitotic cycle 14 [16]. No histone modifications are observed along the  neighboring regions