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. 2017 Jul 4;10:33. doi: 10.1186/s13072-017-0141-5

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© The Author(s) 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Spectral clustering of chromatin signatures for top 2000 early Zelda sites. Cluster 1 (left) is composed of 620 early Zelda peaks, with an average chromatin signal of asymmetric H3K4me3 with H3K4me1 mark (promoter-like signature). Cluster 2 includes 660 early Zelda peaks and shows symmetric signature of two flanking H3K4me1 nucleosomes, within a larger H3K27me3 region. Cluster 3 (right) includes 720 Zelda peaks and is characterized by almost no modifications. Top row chromatin data from mitotic cycle 14; bottom mitotic cycle 13