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Dissolving 58 kDa PVP MN arrays dissolved after 24 hours’ skin insertion in mouse skin in vivo (A) and dissolved Gantrez® S-97 MN arrays after 24 hours’ skin insertion in mouse skin in vivo (B). Hydrogel-forming MN arrays after removal following 24 hours’ skin insertion in mouse skin in vivo displayed flexibility due to the uptake of interstitial fluid regardless of whether the needle density used was 11 × 11 (C) or 19 × 19 (D).
