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. Author manuscript; available in PMC: 2017 Jul 4.
Published in final edited form as: Hippocampus. 2015 Dec 25;26(6):718–726. doi: 10.1002/hipo.22553

Figure 3.

Figure 3

Effects of BF and MS/vDBB cholinergic lesions on contextual fear memory generalization and extinction memory. A) Complete BF cholinergic lesions resulted in extensive AChE loss in the neocortex and hippocampus. BF cholinergic lesions also induced contextual fear memory generalization, impaired extinction of this generalized contextual fear memory, and impaired acquisition of cued fear extinction. B) MS/vDBB cholinergic lesions resulted in selective AChE loss to the dHipp and mPFC. These lesions also induced context fear memory generalization, impaired extinction of generalized contextual fear memory, and impaired acquisition of cued fear extinction. Bl- Block, FC – fear conditioning, frontopariental cortex - FP.