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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Clin Cancer Res. 2017 Jan 20;23(13):3343–3351. doi: 10.1158/1078-0432.CCR-16-2745

Figure 1. A workflow for sequential treatments with 90Y-DOTA-AR and VTP in mice with established tumor xenografts.

Figure 1

VTP was performed at 4 hours post injection (p.i.) of 90Y-DOTA-AR intended to trap maximum amount of radioactivity in tumors. The radioactivities of 90Y-DOTA-AR in the xenografts were quantitatively measured via CLI at 3.8–4 hours p.i. for initial uptake radioactivity prior to VTP as well as at 24, 48, 72, 96 and 144 hours p.i. of 90Y-DOTA-AR (PC-3 xenografts) or at 24 hours p.i. of 90Y-DOTA-AR (VCaP xenografts). PC-3 tumor growth was also monitored for anti-tumor effect of these therapies.