Figure 1.
Adjusted cumulative incidence curves in joint subgroups defined by ceramide score and intervention group assignment.
Panel A: Adjusted cumulative incidence curves in following joint subgroups: participants with a ceramide score ≥median and randomized to either of the two Mediterranean diet intervention arms, participants with a ceramide score <median and randomized to either of the two Mediterranean diet intervention arms, participants with a ceramide score ≥median and randomized to the control arm, and participants with a ceramide score <median and randomized to the control arm.
Panel B: Adjusted cumulative incidence curves in following joint subgroups: participants with a ceramide score ≥median and randomized to the intervention arm with Mediterranean diet + extra-virgin olive oil, participants with a ceramide score <median and randomized to the intervention arm with Mediterranean diet + extra-virgin olive oil, participants with a ceramide score ≥median and randomized to the control arm, and participants with a ceramide score <median and randomized to the control arm.
Panel C: Adjusted cumulative incidence curves in following joint subgroups: participants with a ceramide score ≥median and randomized to the intervention arm with Mediterranean diet + nuts, participants with a ceramide score <median and randomized to the intervention arm with Mediterranean diet + nuts, participants with a ceramide score ≥median and randomized to the control arm, and participants with a ceramide score <median and randomized to the control arm.
Cumulative incidence curves were adjusted for age (continuous) and sex (male, female), body mass index (kg/m2, continuous), family history of premature coronary heart disease (yes, no), smoking status (current, never, former), histories of hypertension, dyslipidemia, and diabetes (all yes, no)