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. Author manuscript; available in PMC: 2017 Jul 5.
Published in final edited form as: Front Biosci (Landmark Ed). 2009 Jan 1;14:192–209. doi: 10.2741/3240

Figure 2.

Figure 2

Coupled and uncoupled eNOS. (a) Coupled eNOS utilizes O2, L-Arginine and NADPH to produce NO and L-Citrulline (b) eNOS can be uncoupled by BH4 deficiency to produce superoxide rather than NO, which may further reduce available NO by combining with it to form peroxynitrite.