Table 1.
Biophysical parameters.
| Channel | Activation | Inactivation | Window | Recovery | ||||
|---|---|---|---|---|---|---|---|---|
| V1/2 (mV) | k | V1/2 (mV) | k | Peak (mV) | Area | τF (ms) | τS (s) | |
| Kv1.1WT | −25 ± 0.3 | 6 ± 0.3 | −38 ± 0.3 | 3 ± 0.3 | −33 | 1 | 64 ± 14 | 2.5 ± 0.2 |
| Kv1.1WT/F303V | −13 ± 0.3* | 9 ± 0.3* | −34 ± 0.4* | 4 ± 0.3 | −27 | 0.8 | 69 ± 18 | 2.6 ± 0.3 |
| KvF303V | +11 ± 0.4* | 8 ± 0.4* | −18 ± 0.5* | 5 ± 0.5† | −7 | 0.4 | 30 ± 6* | 2.6 ± 0.2 |
| Kv1.1WT/1.2 | −16 ± 0.4 | 9 ± 0.3 | −31 ± 0.9 | 4 ± 0.9 | −26 | 1 | 110 ± 2 | 6 ± 0.1 |
| KvF303V/1.2 | 0 ± 0.5# | 12 ± 0.4# | −22 ± 0.6# | 5 ± 0.5 | −16 | 0.6 | 44 ± 5# | 2 ± 0.1# |
V 1/2 and k represent voltage for half-maximal activation and slope factor determined from Boltzmann fits; mean ± SE. n = 6 for each channel group. *,†Significantly different from Kv1.1WT (*p < 0.0001, †p < 0.005). #Significantly different from Kv1.1WT/1.2 (p < 0.0001).