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. 2017 Jul 4;7:4558. doi: 10.1038/s41598-017-04468-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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STBEV uptake and effect of free HbF visualised by transmission electron microscopy. The normal STBEVs, co-treated with HbF, appear to bind the plasma membrane (a), which is ruffled (b,c) as was also seen in cells treated with PE STBEVs (see Fig. 6b). The STBEVs were internalised into endosomes (d) and transported to intracellular compartments (e,f). The mir-517c is localised predominantly into the ER than in the mitochondria (e,f), also seen in cells treated with PE STBEVs (see Fig. 6e). Abbreviations; E endosome, ER endoplasmic reticulum, MV microvilli, M mitochondria, N nucleus, PM plasma membrane. PLAP labelled with 20 nm and mir-517c labelled with 5 nm colloidal gold.