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. 2017 Jul 4;7:4607. doi: 10.1038/s41598-017-04869-1

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparative analysis of the mouse and dog genomes. We performed a comparative analysis of the mouse and dog genomes to determine whether the syntenic region of ATR1 was selected during the domestication of dogs. We first downloaded gene data for orthologues from Ensembl (Archive EnsEMBL release 67; NCBI m37 for mouse and CanFam2.0 for dog). We then used selective sweep datasets that referred to the domesticated region from previous publications18,19. Overlapping genes between the orthologues and the selective sweep regions were then extracted. (a) Plot of the genes on mouse chromosome 11 expressed in mouse brain (x-axis) against synteny in dogs (y-axis). Triangles are dog chromosome 5, circles are dog chromosome 9. (b–d) Syntenic regions of mouse chromosome 11 in dogs and regions that have been selected during the domestication of dogs, identified by performing genomic comparisons of grey wolves and dogs (vertical blue line) and of 10 domesticated dog breeds (vertical orange line).