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. 2017 Jul 4;7:4591. doi: 10.1038/s41598-017-04843-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Age-dependent diagnostic performance of D-dimer in patients with suspected DVT according to different diagnostic thresholds. Pattern A (left side) illustrates the diagnostic performance of the established D-dimer threshold of 0.5 mg/L FEU. Sensitivity (red line) and specificity (blue line) of D-dimer are displayed according to age for patients with proximal DVT, patients with isolated distal DVT, and in the total sample. Pattern B (right side) depicts the diagnostic performance of optimized D-dimer thresholds for sensitivity (red line) and specificity (blue line) in proximal DVT, isolated distal DVT, and the total sample. Solid lines illustrate age-specific fixed thresholds (for patients < 60 years: 0.25 mg/L FEU D-dimer and for patients ≥ 60 years: 0.5 mg/L FEU D-dimer), whereas dashed lines show an age-dependent threshold (age/100 mg/L FEU D-dimer). DVT, deep vein thrombosis.