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. 2017 Jul 4;7:4555. doi: 10.1038/s41598-017-04027-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Human gene vs. disease multifactorial interaction network. The network shows interactions between genes from significant pathways (ERBB signaling family of tyrosine kinases and ion channels) identified based on the GWAS datasets (Meta3, green nodes; Meta7, light-blue nodes; overlapping genes between Meta3 and Meta7, orange nodes) and the Drosophila transcriptome GSEA. Only human homologs of the respective Drosophila genes with altered expression in the dSur KD flies in relation to controls (Fig. 2) were included. Relationships between the respective genes and biological processes (diabetes, carbohydrate and lipid metabolism, orange; cardiovascular diseases, beige), protein complexes and phenotypes (abnormal sleep and circadian behaviour, blue) are also shown (decreased activity/expression, grey edges with cross bar; increased activity/expression, green colored arrows; modulated activity/expression, green edges with open diamond). Red edges indicate gene expression for flies pooled every 3 h of the 24 hours period (decreasing expression, cross bar; increased expression in relation to wild-type controls, arrows; ratio RNAi/wt). Protein-protein interactions are displayed as black edges; interlinking genes are shown as grey nodes. A list of interactions with literature references is available in the Supplementary Table S8.