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. 2017 Jul 4;7:4555. doi: 10.1038/s41598-017-04027-7

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed genes in dSur KD flies vs. controls. Heat map representing a selection of deregulated transcripts homologs to human genes (indicated in brackets) associated with sleep duration in the meta-analysis results used for the GSEA in (a) “Pooled” (Drosophila pooled every 3 h of the 24 hours period) and (b) “Night” (3 h into the night) conditions. A color-coded scale for the normalized expression values is used as follows: yellow and blue represent high and low expression levels in dSur KD with respect to control, respectively. The expression level of each transcript was calculated as the log2 (dSur KD/control), and the complete lists of differentially expressed genes identified by LIMMA software are provided in the Supplementary Table S7.