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. 2017 Jul 4;7:4598. doi: 10.1038/s41598-017-04832-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Functional analysis of the 93 neuropeptides and 133 receptors. (A) Scatterplot showing the biological process cluster representatives terms from gene ontology (GO) for the 127 neuropeptides in a two-dimensional space derived by applying multidimensional scaling to a matrix of the GO terms’ semantic similarities. Y-axis indicates the similarity of the GO terms; x-axis indicates the log of corrected P-value (bubbles of right corrected P-values are larger). (B) Graph showing significantly enriched cancer-related terms for 93 neuropeptides and 133 receptor genes in human. (C) Venn diagram showing comparative overlap based on four literature-based cancer databases. (D) Venn diagram showing overlap of tumour suppressors and oncogenes.