Table 1.
Function of top 10 genes up- or down-regulated in T1D associated with CVD.
| Gene | Gene Product | Fold Change | P value | Function |
|---|---|---|---|---|
| Up-regulated | ||||
| HMGCS2 | 3-hydroxy-3-methylglutaryl-CoenzymeA synthase2 | 5.40 | 0.003 | Ketogenesis |
| ANKRD1 | Ankyrin repeat domain 1 | 2.12 | 0.007 | Regulate myofibrillar stretch-sensor system |
| PDK4 | Pyruvate dehydrogenase kinase, isoenzyme4 | 2.10 | 0.02 | Inhibits conversion of pyruvate to acetyl CoA |
| NPPA | Natriuretic peptide A | 2.05 | 0.02 | Electrolyte homeostasis |
| SERPINE1 | Serpin peptidase inhibitor | 2.03 | 0.01 | Serine proteinase inhibitor (serpin) superfamily |
| Down-regulated | ||||
| ARNTL | Aryl hydrocarbon receptor nuclear translocator like | 2.89 | 0.03 | Circadian clock |
| SLC41A3 | Solute Carrier family 41 member 3 | 2.58 | 0.0007 | Transmembrane Transport |
| BDH1 | 3-hydroxybutyrate dehydrogenase, type 1 | 2.53 | 0.04 | Mitochondrial membrane enzyme |
| CDKN1A | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 2.12 | 0.01 | Regulator of cell cycle progression at G1 |
| MYOT | Myotilin | 2.10 | 0.03 | Stability of thin filaments during muscle contraction |