Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Jul 4;7:4579. doi: 10.1038/s41598-017-04587-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Islet- and LHX3-family LIM-HD proteins and interactors. (A) Simple phylogenetic tree diagram of LIM-HD proteins from mouse (black) and C. elegans (green) illustrating the LIM-HD families; Uniprot accession codes are provided. Branches and relationships are derived from analysis of these proteins using CLUSTAL OMEGA and CLUSTAL PHYLOGENY. Distances are not to scale. (B) Schematic of evolutionary relationships in metazoans. Hs – Homo sapiens; Ms – Mus musculus; Gg – Gallus gallus, Xl – Xenopus laevis, Dr – Danio rerio, Ci – Ciona intestinalis, Pd - Platynereis dumerilii, Ce -Caenorhabditis elegans, Dm – Drosophila melanogasta, Nv - Nematostella vectensis, Ml - Mnemiopsis leidyi, Aq- Amphimedon queenslandica, Ta - Trichoplax adhaerens. The branchpoints between some basal metazoans are controversial^{70, 71} and not indicated here. (C) Distinct transcriptional complexes drive different transcription programs in adjacent cell types in the developing ventral spinal cord in vertebrates. (D) Sequence identity (% compared to Hs proteins) between domains in metazoan LHX3 and ISL1 proteins. No domain identified (*), substantially truncated domain identified (^#). No PdLHX3 gene was found.