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. 2017 Jul 4;7:4579. doi: 10.1038/s41598-017-04587-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Islet- and LHX3-family LIM-HD proteins from C. elegans interact. (A) Manual alignment of experimentally determined LIM-interaction domains from mouse ISL1 and ISL2 and a predicted LID from LIM-7. The LIM1 and LIM2 binding motifs as previously identified for ISL1 and ISL2 are indicated; the spacer is the sequence between the binding motifs. (B) Schematics of LIM-7 and CEH-14 and constructs used in yeast two-hybrid (Y2H) assays showing the LIM1 and LIM2, homeodomain (HD) and predicted LIM interaction domain (LID). (C) Y2H data indicate a direct interaction between LIM-7_LID and CEH-14_LIM1+2. The original images for the yeast plates, including additional controls are shown in Supplemental data Figure S1.