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. 2017 Jul 5;11:191. doi: 10.3389/fncel.2017.00191

Figure 6.

Figure 6

Neuroinflammation can be reduced by JTE-013 infusion. (A) Representative staining for IBA1 (red) in the cortex from DMSO or JTE-013 infused mice administered saline (vehicle) or AOM. DAPI (blue) was used to stain nuclei. The scale bar on the figure represents 50 μm. (B) Quantification of relative IBA1 field staining in the cortex from DMSO or JTE-013-infused mice administered vehicle or AOM. (C) Relative CCL2 mRNA expression in the cortex from DMSO or JTE-013-infused mice administered vehicle or AOM. (D) CCL2 concentrations in cortex homogenates normalized to total protein concentrations from DMSO or JTE-013-infused mice administered vehicle or AOM. (E) Relative cortex IL-6 mRNA expression in DMSO or JTE-013-infused mice administered vehicle or AOM. (F) Cortex IL-6 concentrations in homogenates normalized to total protein concentrations from DMSO or JTE-013-infused mice administered vehicle or AOM. (G) Relative TNFα mRNA expression in the cortex from DMSO or JTE-013-infused mice administered vehicle or AOM. (H) TNFα concentrations in cortex homogenates normalized to total protein concentrations from DMSO or JTE-013-infused mice administered vehicle or AOM. *p < 0.05 compared to DMSO-infused vehicle-treated mice, #p < 0.05 compared to DMSO-infused AOM-treated mice. n = 3 or greater for all analyses.