Table 3.

The effects of vitamin E on metabolic parameters in hyperlipidemic animal models.

Researcher (Year)	Animal model	Types of diet/induction	Treatment and dose	Mode	Duration	Changes in metabolic parameters
						Obesity	Hyperglycemia	Dyslipidemia
(A) FEMALE ANIMALS
Qureshi and Peterson, 2001	White Leghorn female chickens	Corn-soybean diet	Rice bran TRF (50 ppm) + lovastatin (50 ppm)	Oral	4 weeks	–	–	↓
Yu et al., 2006	White Leghorn female chickens	Cholesterol-free corn-soy diet	TRF (500 ppm)	Oral	4 weeks	↔	–	↓
			αTF (500 ppm)
			αT3 (500 ppm)
			γT3 (500 ppm)
			δT3 (500 ppm)
Qureshi et al., 2011	White Leghorn female chickens	Corn-soy diet	δT3 (50 ppm/kg diet)	Oral	4 weeks	↓	–	↓
(B) MALE ANIMALS
Raederstorff et al., 2002	Male golden Syrian hamsters	Coconut-supplemented diet	γT3 (58 or 263 mg/kg/day)	Oral	4 weeks	–	–	↓
			Mixed T3 (263 mg/kg/day)
Salman Khan et al., 2011	Hyperlipidemic male golden hamsters	LPS	Tocomin (10 mg/day)	Oral	10 days	–	–	↓
Qureshi et al., 2001a	Hereditary hypercholesterolemic swine	Corn-soybean diet	TRF (50 mg/kg diet)	Oral	6 weeks	–	↓	↓
			γT3 (50 mg/kg diet)
Khor and Ng, 2000	Male golden Syrian hamsters	Semi-synthetic diet	αTF (30 ppm)	Oral	45 days	–	–	↑
Iqbal et al., 2003	Hypercholesterolemic female Sprague-Dawley rats	7,12-dimethylbenz [α]anthracene (DMBA)	Rice bran TRF (10 mg/kg/day)	Oral	6 months	–	–	↓
Minhajuddin et al., 2005	Male albino rats	Atherogenic diet	TRF (8 – 50 mg/kg)	Oral	1 week	–	–	↓
Zaiden et al., 2010	Hypercholesterolemic mice (LDLr−/−)	–	γδT3 (50 mg/kg)	Oral	4 weeks	↔	–	↓
Burdeos et al., 2012	Male F344 rats	High-fat (35%) diet	αTF (10 mg)	Oral	3 weeks	–	–	↔
			Rice bran TRF			↓	–	↓
Allen et al., 2015	Male Sprague-Dawley rats	Choline-deficient diet	αTF (200 mg/kg/day)	Oral	8 weeks	↔	↔	↔
Shibata et al., 2016	Male F344 rats	Western diet	αTF (50 mg/day)	Oral	3 weeks	–	↔	↔
			Rice bran T3 (11.1 mg/day)			–	↔	↓
			αTF (50 mg/day) + rice bran T3 (11.1 mg/day)			–	↔	↔