Table 1.
Concentration of agonists causing 50% inhibition (IC50 of the adenosine triphosphate (ATP)-mediated release of interleukin-1β (IL-1β) in monocytes and the nAChR composition needed for the signaling.
| Endogenous agonist | Approximate IC50 | Required nAChR subunits |
|---|---|---|
| ACh | 10 μM (Hecker et al., 2015) | α7, α9, α10 |
 | ||
| PC | 10 μM (Hecker et al., 2015) | α7, α9, α10 |
 | ||
| LPC | 1 μM | α9, α10 |
 | ||
| G-PC | 1 μM | α9, α10 |
 | ||
| DPPC | 10 μM (Backhaus et al., 2017) | α9 and α7 or α10 |
 |
ACh, acetylcholine; DPPC, dipalmitoylphosphatidylcholine; G-PC, glycero- phosphocholine; LPC, lysophosphatidylcholine; nAChR, nicotinic ACh receptor; R, fatty acid residue C16:0.