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. Author manuscript; available in PMC: 2017 Nov 1.
Published in final edited form as: Tob Control. 2016 Oct 3;25(Suppl 2):ii50–ii54. doi: 10.1136/tobaccocontrol-2016-053209

Figure 4. Comparison of menthol and nicotine sensitivity of wild-type and Trpm8−/− mice in the two bottle test.

Figure 4

(A) Consumption volumes averaged over 4 nights of wild-type mice given the choice of water only (blue) or water plus menthol (25, 50, 100 μg/ml, green). Error bars represent SEM. ***:p<0.001; n=3 per group.

(B) Consumption volumes averaged over 4 nights of Trpm8−/− mice given the choice of water only (blue) or water plus menthol (25, 50, 100 μg/ml, green). Error bars represent SEM. ****:p<0.0001; n=4 per group.

(C) Consumption volumes averaged over 4 nights of wild-type mice given the choice of water only (blue) or water plus nicotine (100μg/ml or 200μg/ml). n=5 per group.

(D) Consumption volumes averaged over 4 nights of Trpm8−/− mice given the choice of water only (blue) or water plus nicotine (100μg/ml or 200μg/ml). n=4 per group.