Table 2.
TCF7L2 allele distribution among GDM cases and controls in the included studies
| Author (year) | Variant (minor allele) | No. cases | Genotypes in GDM case | Genotypes in GDM control | Minor allele frequency (%) | P for HWE | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case | Control | AA | AB | BB | AA | AB | BB | Case | Control | |||
| Aris (2012) | rs7903146(T) | 173 | 114 | 129 | 43 | 1 | 99 | 15 | 0 | 87 | 93.4 | 0.686 |
| Cho (2009) | 868 | 627 | 2 | 63 | 803 | 0 | 31 | 596 | 3.9 | 2.5 | 1 | |
| de Melo (2015) | 200 | 200 | 20 | 104 | 76 | 16 | 86 | 98 | 36 | 29.5 | 0.633 | |
| Freathy (2010) | 614 | 3,811 | 75 | 246 | 293 | 370 | 1,557 | 1,884 | 32.2 | 30.1 | 0.29 | |
| Freathy (2010) | 384 | 1,332 | 0 | 46 | 338 | 3 | 108 | 1,211 | 6 | 4.3 | 0.73 | |
| Huerta‐Chagoya (2015) | 408 | 342 | 19 | 124 | 265 | 10 | 67 | 265 | 19.9 | 12.7 | 0.03 | |
| Kan (2014) | 100 | 100 | 1 | 15 | 84 | 0 | 5 | 95 | 8.5 | 5 | >0.05 | |
| Klein (2012) | 125 | 125 | 5 | 112 | 8 | 8 | 107 | 10 | 48.8 | 49.2 | NA | |
| Lauenborg (2009) | 276 | 2,353 | 33 | 125 | 118 | 198 | 863 | 1,292 | 34.6 | 26.8 | >0.05 | |
| Pagan (2014) | 45 | 24 | 8 | 18 | 19 | 2 | 12 | 10 | 38 | 33 | 1 | |
| Papadopoulou (2011) | 803 | 1,110 | 88 | 352 | 363 | 82 | 384 | 644 | 32.9 | 24.7 | 0.02 | |
| PAPPA (2011) | 148 | 107 | 18 | 81 | 49 | 7 | 38 | 62 | 39.53 | 24.29 | 0.792 | |
| Reyes‐López (2014) | 90 | 108 | 6 | 29 | 55 | 4 | 23 | 81 | 23 | 14 | NA | |
| RIZK (2011) | 40 | 74 | 6 | 18 | 16 | 8 | 37 | 29 | 37.5 | 37.2 | 0.706 | |
| Shaat (2007) | 585 | 1,111 | 59 | 255 | 271 | 69 | 392 | 650 | 31.9 | 23.8 | 0.363 | |
| Shi (2014) | 100 | 100 | 24 | 36 | 40 | 7 | 38 | 55 | 42 | 26 | >0.05 | |
| Thomas (2014) | 117 | 49 | 16 | 46 | 55 | 4 | 18 | 27 | 33.3 | 26.5 | 0.452 | |
| Vcelak (2012) | 261 | 376 | 17 | 102 | 142 | 35 | 185 | 156 | 33.8 | 26.1 | 0.067 | |
| Zhang (2015) | 113 | 115 | 0 | 17 | 96 | 0 | 5 | 110 | 7.52 | 2.17 | >0.05 | |
| Cho (2009) | rs12255372(T) | 867 | 630 | 0 | 7 | 860 | 0 | 2 | 628 | 0.4 | 0.2 | NA |
| de Melo (2015) | 200 | 200 | 20 | 88 | 92 | 23 | 75 | 102 | 32 | 30.3 | 0.633 | |
| Klein (2012) | 125 | 125 | 39.6 | 28 | NA | |||||||
| Pagan (2014) | 45 | 25 | 6 | 20 | 19 | 2 | 14 | 9 | 36 | 36 | 0.4095 | |
| Papadopoulou (2011) | 801 | 1,102 | 81 | 333 | 387 | 84 | 385 | 633 | 30.9 | 25.1 | 0.02 | |
| Reyes‐López (2014) | 90 | 108 | 7 | 23 | 60 | 2 | 5 | 101 | 20 | 5 | NA | |
| RIZK (2011) | 40 | 74 | 6 | 28 | 6 | 11 | 38 | 25 | 50 | 40.5 | 0.108 | |
| Shi (2014) | 100 | 100 | 0 | 0 | 100 | 0 | 0 | 100 | 0 | 0 | >0.05 | |
| Vcelak (2012) | 260 | 376 | 22 | 115 | 124 | 23 | 147 | 206 | 30 | 25.7 | 0.067 | |
| Watanabe (2007) | 94 | 58 | 39.4 | 20.7 | NA | |||||||
| Huerta‐Chagoya (2015) | rs7901695(C) | 408 | 342 | NA | NA | NA | NA | NA | NA | 20.3 | 13.6 | 0.03 |
| Pagan (2014) | 45 | 25 | 8 | 20 | 17 | 2 | 13 | 10 | 40 | 34 | 0.6626 | |
| Papadopoulou (2011) | 794 | 1,102 | 95 | 356 | 343 | 90 | 405 | 607 | 34.4 | 26.5 | 0.02 | |
| Stuebe (2014) | 56 | 842 | 9 | 30 | 17 | 70 | 357 | 415 | 42.9 | 29.5 | >0.05 | |
| Stuebe (2014) | 24 | 366 | 4 | 15 | 5 | 79 | 162 | 121 | 47.9 | 43.7 | >0.05 | |
| Vcelak (2012) | 261 | 376 | 25 | 130 | 106 | 24 | 147 | 205 | 34.4 | 26.9 | 0.067 | |
| Hui (2011) | rs290487(C) | 480 | 631 | 90 | 220 | 170 | 88 | 282 | 261 | 41.7 | 36.3 | 0.2076 |
| Shi (2014) | 100 | 90 | 12 | 36 | 52 | 6 | 34 | 50 | 30 | 33 | >0.05 | |
| Wang (2013) | 70 | 70 | 11 | 37 | 22 | 9 | 33 | 28 | 42.2 | 36.5 | NA | |
| Hui (2011) | rs11196205(G) | 479 | 623 | 461 | 18 | 0 | 591 | 32 | 0 | 98.1 | 97.4 | 1 |
| Shi (2014) | 100 | 100 | 99 | 0 | 1 | 100 | 0 | 0 | 99 | 100 | >0.05 | |
| Hui (2011) | rs11196218(A) | 471 | 625 | 30 | 201 | 240 | 43 | 256 | 326 | 27.7 | 27.4 | 0.1449 |
| Liu (2014) | 144 | 144 | 9 | 58 | 77 | 5 | 53 | 86 | 26 | 22 | >0.05 | |
| Huerta‐Chagoya (2015) | rs12243326(C) | 408 | 342 | NA | NA | NA | NA | NA | NA | 16.8 | 9.6 | 0.03 |
| Pagan (2014) | 45 | 25 | 7 | 20 | 18 | 2 | 13 | 10 | 38 | 34 | 0.6626 | |
| Huerta‐Chagoya (2015) | rs4506565(T) | 408 | 342 | NA | NA | NA | NA | NA | NA | 21.3 | 14 | 0.03 |
| Pagan (2014) | 45 | 25 | 9 | 20 | 16 | 0 | 12 | 13 | 42 | 24 | 0.2762 | |
GDM, gestational diabetes mellitus; HWE, Hardy–Weinberg equilibrium; NA, not available.