Table 3.
Multivariate Cox proportional hazard models for the incidence of cardiovascular disease and all‐cause mortality
| CVD incidence (event/patients 78/618) | All‐cause mortality (event/patients 56/646) | |||||||
|---|---|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 1 | Model 2 | |||||
| HR (95% CI) | P‐value | HR (95% CI) | P‐value | HR (95% CI) | P‐value | HR (95% CI) | P‐value | |
| Mean 2h‐PBBG (1 mmol/L) | 1.13 (1.04–1.23) | 0.004 | 1.11 (1.02–1.21) | 0.013 | 1.14 (1.04–1.25) | 0.007 | 1.15 (1.05–1.26) | 0.003 |
| Mean HbA1c (%) | 0.99 (0.72–1.37) | 0.95 | 0.85 (0.61–1.18) | 0.33 | 0.97 (0.65–1.43) | 0.81 | 0.99 (0.65–1.51) | 0.98 |
| No. 2h‐PBBG measurements† | 0.84 (0.69–1.02) | 0.083 | 0.85 (0.70–1.03) | 0.088 | 0.80 (0.63–1.01) | 0.062 | 0.79 (0.63–1.01) | 0.055 |
| Age (10 years) | 1.74 (1.32–2.28) | <0.0001 | 1.42 (1.06–1.89) | 0.019 | 3.58 (2.67–4.80) | <0.0001 | 3.93 (2.79–5.54) | <0.0001 |
| Women/men | 0.61 (0.32–1.19) | 0.15 | 0.66 (0.33–1.33) | 0.25 | 0.94 (0.50–1.76) | 0.85 | 0.91 (0.46–1.79) | 0.78 |
| Duration of diabetes (5 years) | – | – | 1.32 (1.15–1.53) | <0.0001 | – | – | 0.94 (0.80–1.11) | 0.45 |
| Mean BMI (kg/m2) | – | – | 0.94 (0.85–1.03) | 0.18 | – | – | 0.97 (0.87–1.08) | 0.60 |
| Mean SBP (10 mmHg) | – | – | 1.15 (0.95–1.40) | 0.16 | – | – | 1.22 (0.97–1.55) | 0.091 |
| Mean TC/HDL‐C | – | – | 1.77 (1.41–2.22) | <0.0001 | – | – | 0.85 (0.64–1.15) | 0.29 |
| Smoking status | – | – | 0.73 (0.44–1.22) | 0.23 | – | – | 1.28 (0.67–2.46) | 0.46 |
†ln‐transformed. 2h‐PBBG, 2‐h post‐breakfast blood glucose; BMI, body mass index; CI, confidence interval; CVD, cardiovascular disease; HbA1c, glycosylated hemoglobin; HR, hazard ratio; SBP, systolic blood pressure; TC/HDL‐C, total cholesterol/high‐density lipoprotein cholesterol.