Table 3. Common complications after EPP [adapted from Taioli et al. (24). Meta-analysis of survival after pleurectomy decortication versus extrapleural pneumonectomy in mesothelioma] (including studies with 100 or more EPPs completed).

Publication	No. of patients in study	No. of EPPs completed	Overall morbidity	Complications [n]
Mordant et al., 2016 (6)	126	126	CTX: 29.7%, IMRT: 35.5%	AF [21]
Sharkey et al., 2016 (7)	362	133	37.15%	AF [29], BPF [9], PE [3], PF [11]
Stahel et al., 2015 (8)	151	113	NR	BPF [4], PE [3]
Bovolato et al., 2014 (9)	1,365	301	21.6%	AF [32], ARDS [1], BPF [3], DVT [2], PE [3], PF [3]
Lauk et al., 2014 (10)	251	251	major: 30%	AF [67], ARDS [3], BPF [20], PE [9], PF [12]
Spaggiari et al., 2014 (12)	518	518	major: 26.3%	AF [18.7%], BPF [14]
Flores et al., 2008 (25)	663	385	NR	DVT [3], PE [6]
Rice, 2007 (18)	100	100	73%	ARDS [8], BF [2], DVT [3], PE [1], PF [3]
Sugarbaker et al., 1999 (20)	183	183	50%, major: 24.5%, minor: 41%	AF [68], DVT [4], PE [3], PF [2]

AF, atrial fibrillation; ARDS, adult respiratory distress syndrome; BPF, bronchopleural fistula; DVT, deep vein thrombosis; PE, pulmonary embolism; PF, patch failure; EPP, extrapleural pneumonectomy; IMRT, intensity-modulated radiotherapy; CTX, chemotherapy; NR, not reported.