Table 4.

Mean increase in aorta size in patients with Marfan syndrome.

Source	Sample size	Growth rate (mm per year)a
		Men	Women
(Jondeau, Detaint et al., 2012)	N = 762	0.50 ± 0.89
(Lazarevic, Nakatani et al., 2006)	N = 43	1.5 ± 1.3
(Meijboom, Timmermans et al., 2005)	N = 221	0.42	0.38
(Kornbluth, Schnittger et al., 1999)	N = 57	Up to 2 mm per year
(Shores, Berger et al., 1994)	N = 70	0.84
(Roman, Rosen et al., 1993)	N = 113	1.4 ± 0.5 (complications group) 0.9 ± 0.8 (no complications group)
(Hwa, Richards et al., 1993)	N = 40	1.5	1.8
		0.36	0.27

^aCompared to the 1 mm per decade observed in normal patients (refer to natural history section).