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. Author manuscript; available in PMC: 2017 Jul 5.
Published in final edited form as: Curr Opin Genet Dev. 2014 May 8;25:126–130. doi: 10.1016/j.gde.2014.01.002

Figure 2. Model for local recycling of polymerase and transcription factors among neighboring genes.

Figure 2

(a) Schematic cartoon of portion of chromosome with six tandem inactive genes containing paused Pol II (multicolor triangles indicate Pol II associated with respective genes). (b) Upon activation of these genes, nucleoplasmic pools of Pol II as well as other transcription factors (for simplicity transcription factors excluded from image) are recruited to genes. (c) As transcription proceeds, the local concentration of polymerases that have completed a round of RNA synthesis builds up around genes. These polymerases can then be shared among neighboring genes to reinitate transcription.