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. Author manuscript; available in PMC: 2018 Apr 12.
Published in final edited form as: Sci Transl Med. 2017 Apr 12;9(385):eaai9321. doi: 10.1126/scitranslmed.aai9321

Fig. 1. Overall gene expression profile in peripheral blood shows distinct phases during EVD and recovery.

Fig. 1

(A) Kinetics of EBOV NP mRNA and vRNA in PBLs as measured by strand-specific qRT-PCR during course of illness. Serum EBOV GP RNA qRT-PCR data previously published in (12) are shown for comparison with PBL replication. (B) Heatmap showing expression levels of genes (n = 8660 sequences) that showed ≥2-fold change in expression level in at least 30% of time points relative to a pool of 29 healthy adult volunteers. For all figures, each heatmap column represents gene expression data from a microarray experiment comparing patient peripheral blood at individual time points relative to pooled RNA isolated from peripheral blood from healthy volunteers (n = 29). Genes shown in red were increased, genes shown in blue were decreased, and genes in black indicate no change in expression in EVD patient relative to healthy volunteers. (C) Pairwise Pearson correlation coefficient similarity matrix of expression values of these 8660 sequences. *Previously reported in (12).