Table 2.
Baseline clinical and therapeutic characteristics of patients at enrolment according to low or high loop diuretic dose. The association among studied variables and baseline high diuretic dose at univariate regression analysis is reported.
| Baseline LDD | Baseline HDD | Univariate regression analysis OR (95% CI) |
p | |
|---|---|---|---|---|
| Number | 153 | 34 | ||
| Age (years) | 65 ± 13 | 67 ± 12 | 1.04 (0.90–1.21) | 0.556 |
| Ischemic cardiomyopathy (%) | 37 | 53 | 1.13 (0.98–1.31) | 0.092 |
| Diabetes mellitus (%) | 21 | 41 | 1.19 (1.04–1.38) | 0.013 |
| Arterial Hypertension (%) | 61 | 65 | 1.03 (0.89–1.19) | 0.673 |
| NYHA class | 2.2 ± 0.5 | 2.36 ± 0.5 | 1.32 (1.15–1.51) | < 0.001 |
| Body mass index (kg/m2) | 28 ± 4 | 28 ± 5 | 0.99 (0.86–1.14) | 0.880 |
| Systolic arterial pressure (mm Hg) | 120 ± 15 | 115 ± 14 | 0.87 (0.75–1.0) | 0.052 |
| GFR-EPI (ml/min/1.73 m2) | 71 ± 24 | 63 ± 23 | 0.87 (0.76–1.01) | 0.066 |
| NT-proBNP (pg/ml)a | 1035 ± 1219 | 2356 ± 1974 | 1.42 (1.24–1.62) | < 0.001 |
| LVEF (%) | 35 ± 9 | 29 ± 10 | 0.77 (0.67–0.88) | < 0.001 |
| MR (a.u.) | 1.5 ± 0.9 | 2.2 ± 1.4 | 1.3 (1.13–1.49) | < 0.001 |
| TR (a.u.) | 1.3 ± 0.9 | 1.9 ± 1.1 | 1.29 (1.12–1.48) | < 0.001 |
| TAPSE (mm) | 19 ± 4 | 17 ± 5 | 0.77 (0.67–0.89) | < 0.001 |
| PASP (mm Hg) | 35 ± 10 | 43 ± 12 | 1.44 (1.25–1.66) | < 0.001 |
| CVP > 5 mm Hg (%) | 11 | 38 | 1.34 (1.17–1.54) | < 0.001 |
| RRI | 69 ± 9 | 76 ± 6 | 1.39 (1.22–1.60) | < 0.001 |
LDD: low diuretic dose. HDD: high diuretic dose. For the remaining abbreviations see table 1.
a
After log-transformation.