Table 3.
Clinical and pathologic features of sclerosing mucoepidermoid carcinomas with eosinophilia in the literature with inclusion of our nine cases
| Literature review and current study | |
|---|---|
| Sex | |
| Females | 44 (88%, n = 50) |
| Males | 6 (12%, n = 50) |
| Age (years) | |
| Mean | 56.1 |
| Range | 30–89 |
| Clinical presentation | |
| Painless mass | 36 (80%, n = 45) |
| Compressive symptoms | 4 (9%, n = 45) |
| Hoarseness | 2 (4%, n = 45) |
| Incidental | 2 (4%, n = 45) |
| Lymphadenopathy | 1 (2%, n = 45) |
| Unknown | 5 |
| Tumor location | |
| Lateral lobe | 38 (88%, n = 43) |
| Isthmus | 1 (2%, n = 43) |
| Diffuse involvement | 4 (9%, n = 43) |
| Unknown | 7 |
| Tumor size (cm) | |
| Mean | 4.3 |
| Range | 0.5–13 |
| Extrathyroidal extension | |
| Present | 21 (47%, n = 45) |
| Absent | 24 (53%, n = 45) |
| Unknown | 5 |
| Lymph node metastasis at time of presentation | 18 (36%, n = 50) |
| Synchronous or metachronous papillary thyroid carcinoma | 9 (18%, n = 50) |
| Background chronic lymphocytic thyroiditis | |
| Present | 45 (96%, n = 47) |
| Absent | 2 (4%, n = 47) |
| Unknown | 3 |
| Immunohistochemistry # of cases with positive staining/total # of cases | |
| Thyroglobulin | 4/44 (9%) |
| TTF-1 | 11/17 (65%) |
| P63 | 19/19 (100%) |
| PAX8 | 1/9 (11%) |
| Treatment | |
| Surgery only | 30 (65%, n = 46) |
| Surgery and radiation ± chemotherapy or radioactive iodine | 16 (35%, n = 46) |
| Unknown | 4 (16%) |