Table 6.
Partially and fully adjusted models of the association between the presence of symptoms and concurrent culture positivity during tuberculosis therapy in Tuberculosis Trials Consortium studies 27 and 28
| Term | Partially Adjusted Model |
Fully Adjusted Model |
||
|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | |
| Symptoms | ||||
| Productive cough | 2.27 (1.90–2.72) | <0.001 | 1.71 (1.41–2.08) | <0.001 |
| Fever | 1.26 (0.83–1.91) | 0.28 | 1.25 (0.80–1.94) | 0.33 |
| Sweats | 0.95 (0.66–1.38) | 0.81 | 0.96 (0.63–1.46) | 0.84 |
| Time on therapy* | ||||
| Weeks 2–8 | 0.66 (0.63–0.68) | <0.001 | 0.60 (0.57–0.63) | <0.001 |
| Weeks 8–16 | 0.75 (0.71–0.79) | <0.001 | 0.73 (0.70–0.77) | <0.001 |
| Weeks 16–24 | 0.90 (0.82–1.00) | 0.042 | 0.90 (0.82–0.99) | 0.024 |
| Weight† | ||||
| Underweight at diagnosis | 1.22 (0.96–1.57) | 0.11 | ||
| Gained > 4 kg | 0.88 (0.59–1.31) | 0.53 | ||
| Any weight loss | 0.93 (0.58–1.48) | 0.75 | ||
| Missing weight change | 0.81 (0.62–1.07) | 0.14 | ||
| Severity of disease at baseline | ||||
| Smear ≥ 1 AFB/field at 1,000× | 1.93 (1.49–2.51) | <0.001 | ||
| Cavitary disease | 1.85 (1.41–2.43) | <0.001 | ||
| Bilateral disease | 1.59 (1.25–2.03) | <0.001 | ||
| Other | ||||
| African site | 2.73 (2.05–3.64) | <0.001 | ||
| HIV positive | 0.67 (0.47–0.97) | 0.032 | ||
Definition of abbreviations: AFB = acid-fast bacilli; CI = confidence interval; OR = odds ratio.
*
Time on therapy was modeled as three separate continuous variables, each with different slopes. The odds ratio represents weekly change in odds during the indicated time period since start of therapy.
†
Weight change over Weeks 0 to 8, with a gain of 0–4 kg as referent.