Table 1.
Clinical and echocardiographic characteristics of the patients in this study (n = 123).
| Variable | Group 1 Mean LV thickness < 12 mm (n = 47) |
Group 2 CHF(−) and BNP < 100 pg/mL (n = 35) |
Group 3 CHF(+) or BNP ≥ 100 pg/mL (n = 41) |
|---|---|---|---|
| Age, year | 44 ± 13 | 62 ± 12* | 63 ± 12* |
| Gender (male/female), n | 22/25 | 26/9 | 19/22 |
| Type of mutation V30M/non-V30M |
47/0 | 34/1 (S50R) | 33/8 [D38A (3), S50I (1), E54K (1), E42G(1), S50R (1), H88R (1)] |
| Systolic blood pressure, mm Hg | 112 ± 10 | 120 ± 19 | 107 ± 17§ |
| Diastolic blood pressure, mm Hg | 71 ± 10 | 78 ± 13# | 65 ± 12#,† |
| Heart rate, bpm | 70 ± 13 | 61 ± 11‖ | 61 ± 11‡ |
| Left atrial diameter, cm | 3.33 ± 0.47 | 4.09 ± 0.67⁎ | 4.24 ± 0.70⁎ |
| Left atrial volume max, mL | 48 ± 18 | 68 ± 28‖ | 81 ± 28⁎,⁎⁎ |
| Left atrial volume min, mL | 21 ± 10 | 34 ± 20# | 54 ± 27⁎,† |
| Left atrial emptying fraction, % | 56 ± 9 | 52 ± 9 | 36 ± 14⁎,† |
| LV end-diastolic diameter, cm | 4.35 ± 0.42 | 4.37 ± 0.46 | 4.30 ± 0.48 |
| LV end-systolic diameter, cm | 2.52 ± 0.38 | 2.69 ± 0.35 | 2.80 ± 0.49‖ |
| LV fractional shortening, % | 42.2 ± 6.9 | 38.5 ± 5.5 | 34.9 ± 7.1⁎,§ |
| LV thickness (septum), cm | 1.00 ± 0.15 | 1.63 ± 0.30⁎ | 1.92 ± 0.39⁎,† |
| LV thickness (posterior), cm | 0.92 ± 0.16 | 1.38 ± 0.24⁎ | 1.66 ± 0.32⁎,† |
| LV end-diastolic volume, mL | 50 ± 15 | 54 ± 11 | 56 ± 16 |
| LV end-systolic volume, mL | 19 ± 6 | 21 ± 5 | 25 ± 9‡ |
| LV ejection fraction, % | 62 ± 5 | 61 ± 5 | 55 ± 10‡,§ |
| Plasma BNP, pg/mL | 30.3 ± 25.0 | 48.0 ± 24.6 | 315.5 ± 282.4⁎,† |
⁎
P < 0.0001 vs. group 1.
†
P < 0.0001 vs. group 2.
‡
P < 0.001 vs. group 1.
§
P < 0.01 vs. group 2.
‖
P < 0.01 vs. group 1.
#
P < 0.05 vs. group 1.
⁎⁎
P < 0.05 vs. group 2.