Table 3.

Regression analysis between gut microbiota and BMI levels

Overweight vs. Normal	Age- and sex- adjusted		Multivariate adjusted
	Coefficienta	Adj. P valueb	Coefficienta	P value	Adj. P valueb
Cyanobacteria YS2c	0.618	2.63 × 10−9	0.035	0.700	1
Desulfovibrio d	0.435	9.08 × 10−5	−0.101	0.273	1
Bacteroidales unknown family unknown genusd	0.403	2.48 × 10−4	0.314	0.001	0.068
Paraprevotellaceae CF231c	0.360	4.58 × 10−4	0.463	2.13 × 10 −7	1.51 × 10 −5
Acidaminococcus d	0.331	0.002	−0.073	0.403	1
Lactobacillales unknown family unknown genusc	0.174	0.031	0.080	0.333	1
Lactococcus e	0.152	0.042	0.099	0.064	1
Eggerthella e	−0.155	0.005	−0.103	0.022	1
Obese vs. Normal
Acidaminococcus d	0.498	3.90 × 10−8	0.378	2.89 × 10 −5	0.002
Paraprevotellaceae CF231c	0.463	7.32 × 10−6	0.284	0.003	0.181
Megasphaera e	0.443	1.79 × 10−5	0.355	0.002	0.146
Mitsuokella c	0.302	0.034	0.217	0.013	0.946
Eggerthella e	−0.162	0.003	−0.073	0.356	1
Christensenellaceae unknown genusd	−0.152	0.031	−0.055	0.003	0.230
Clostridiales unknown family unknown genus	−0.063	0.004	−0.063	5.24 × 10 −5	0.004
Obese vs. Overweight
Acidaminococcus d	0.329	0.001	0.504	2.64 × 10 −8	1.87 × 10 −6
Mitsuokella c	0.271	0.007	0.381	1.10 × 10 −6	2.61 × 10 −5
Akkermansia	−0.225	0.038	−0.225	0.001	0.038
Christensenellaceae unknown genusd	−0.179	0.003	−0.170	0.020	0.126
Adlercreutzia	0.139	0.007	0.139	9.34 × 10 −5	0.007

^aCoefficient (log2 ratio) driven by zero-inflated Gaussian mixture model (fitZig) using metageomeSeq package

^bApplied by Bonferroni multiple comparison correction

^cAdditionally adjusted for fat and total calorie intake

^dAdditionally adjusted for fiber and total calorie intake

^eAdditionally adjusted for carbohydrate and total calorie intake

Coefficient with Adj. P value < 0.05 shown in italic