Table 1.
Drug category | Class | Drugs | Daily dosage |
---|---|---|---|
Direct acting antivirals (DAA) | NS3 inhibitors (proteases) | Asunaprevir (ASV) Boceprevir (BOC) Paritaprevir (PTV) Simeprevir (SMV) Telaprevir (TVR) |
200 mg/day in 2 doses 2,400 mg/day in 3 doses 150 mg/day in 1 dose* 150 mg/day in 1 dose 2,250 mg/day in 2 doses |
NS5B inhibitors (polymerases) | Dasabuvir (DSV) Sofosbuvir (SOF) |
500 mg/day in 2 doses 400 mg/day in 1 dose** |
|
NS5A inhibitors | Daclatasvir (DCV) Ledipasvir (LDV) Ombitasvir (OBV) |
60 mg/day in 1 dose 90 mg/day in 1 dose** 25 mg/day in 1 dose* |
|
Interferons | Pegylated interferons α (PegIFNα) | PegIFNα2α PegIFNα2β |
180 μg/week 1.5 μg/kg/week |
Others | Ribavirin (RBV) | 1,000 or 1,200 mg at body weight < 75 kg or > 75 kg |
PTV and OBV are combined in one tablet with ritonavir (PTV/OBV/r)
SOF can be combined in one tablet with LDV (SOF/LDV)