Skip to main content
. Author manuscript; available in PMC: 2017 Jul 5.
Published in final edited form as: Nat Struct Mol Biol. 2016 Dec 6;23(12):1045–1052. doi: 10.1038/nsmb.3324

Figure 3. Rev-erbα and RORα coordinate rhythmic gene expression at RORE/DR2 elements.

Figure 3

Rev-erb represses transcription by two known major mechanisms: 1) Competes with and jettisons RORα and associated co-activators from chromatin; and 2) Recruits N-CoR/SMRT corepressor complexes harboring HDAC3 to deacetylate nearby chromatin and heterochromatin. The deacetylase activation domain (DAD) of N-CoR and SMRT is required to stimulate HDAC3 activity.