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. Author manuscript; available in PMC: 2017 Jul 5.
Published in final edited form as: Nat Struct Mol Biol. 2016 Dec 6;23(12):1045–1052. doi: 10.1038/nsmb.3324

Figure 4. Temporal view of chromatin and clock factors surrounding rhythmic E-boxes.

Figure 4

Recent work has started to unravel the temporal coordination of the molecular clock, including rhythmic changes to histone modifications, histone deposition and chromatin structure. The classical clock proteins (BMAL1/CLOCK/CRY/PER) recruit several chromatin-modifying proteins and complexes that control the epigenome.