Figure 2.

Megalencephaly with increased brain water content in Glialcam‐null mice. (A) Glialcam‐null mice have larger brains than wild‐type littermates, as shown for these 8‐month‐old animals. (B) Measurements of brain wet and dry weight at postnatal day 7 (P7) #bib3 weeks (w), and at 3, 7, and 12 months (m; n = 3 per genotype per age) show significantly increased brain wet weight (circles) in Glialcam‐null mice (solid line) compared to controls (dotted line) from 3 weeks (P = 0.98 at P7, P = 0.05 at 3 weeks, P = 0.0004 at 3 months). This difference continues to grow (P = 0.0004 at 7 months, P < 0.0001 at 12 months). No differences are present in brain dry weight (squares) between Glialcam‐null and wild‐type mice. Error bars indicate the standard error of the mean.