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SYFSF inhibited the expression of inflammatory cytokine in high-glucose-treated mesangial cells. High glucose induced upregulation of MCP-1 and TNF-α which were suppressed by SYFSF serum in mesangial cells. There was no obvious change of NF-κBp65 expression. HG + S represents the mesangial cells treated with high-glucose medium and serum from rats treated with SYFSF. HG + I represents the mesangial cells treated with high-glucose medium and serum from rats treated with irbesartan.
